Inhibition of CD47 effectively targets pancreatic cancer stem cells via dual mechanism
نویسندگان
چکیده
1 Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain 2 Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, a CR-UK Centre of Excellence, Queen Mary University of London, UK 3 Gastrointestinal Cancer Clinical Research Unit, Clinical Research Programme, CNIO 4 Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK 5 Department of Surgery, Technical University Munich, Munich, Germany
منابع مشابه
Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms.
PURPOSE Pancreatic ductal adenocarcinoma (PDAC) is a cancer of the exocrine pancreas with unmet medical need and is strongly promoted by tumor-associated macrophages (TAM). The presence of TAMs is associated with poor clinical outcome, and their overall role, therefore, appears to be protumorigenic. The "don't eat me" signal CD47 on cancer cells communicates to the signal regulatory protein-α o...
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Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a cancer of the exocrine pancreas with unmet medical need and is strongly promoted by tumor-associated macrophages (TAM). The presence of TAMs is associated with poor clinical outcome, and their overall role, therefore, appears to be protumorigenic. The "don't eat me" signal CD47 on cancer cells communicates to the signal regulatory protein-a ...
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